The second Acts volume follows the gospel outward from Antioch through Paul's three missionary journeys, the council at Jerusalem that settled the place of the law, the preaching at Athens, the long ministry at Ephesus, the arrest in Jerusalem, the successive defenses before Felix, Festus, and Agrippa, and the shipwreck and arrival at Rome where Paul preaches unhindered.

Each volume in the MacArthur New Testament Commentary works verse by verse through the Greek text, explains the passage in its context, and presents its theology with precision, in the service of expository preaching rather than academic debate. The series is written for pastors preparing sermons, teachers preparing lessons, and any believer willing to study carefully, and it is the fruit of more than five decades of pulpit ministry at Grace Community Church.